Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Enteric pathogens are exposed to a dynamic polymicrobial environment in the
gastrointestinal tract. This microbial community has been shown to be important during …

We report an atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI)
mass spectrometry imaging (MSI) setup with a lateral resolution of 1.4 μm, a mass resolution …

CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …

Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS)
impairment, resulting from deficiency of a lysosomal enzyme. Treatment of neuronopathic …

Mass spectrometry imaging (MSI) is a developing technique to measure the spatio-temporal
distribution of many biomolecules in tissues. Over the preceding decade, MSI has been …

There is an increasing appreciation that every cell, even of the same type, is different. This
complexity, when additionally combined with the variety of different cell types in tissue, is …