Developmental origins of metabolic diseases
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …
as obese, while nearly one-third of children globally experience poor growth and …
Placental function in maternal obesity
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …
Biological and pathological mechanisms leading to the birth of a small vulnerable newborn
The pathway to a thriving newborn begins before conception and continues in utero with a
healthy placenta and the right balance of nutrients and growth factors that are timed and …
healthy placenta and the right balance of nutrients and growth factors that are timed and …
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …
[HTML][HTML] IGF2: Development, Genetic and Epigenetic Abnormalities
C Sélénou, F Brioude, E Giabicani, ML Sobrier… - Cells, 2022 - mdpi.com
In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …
knockout mouse models, we have learnt much about the structure of this protein, its role and …
Long term effects of ART: What do animals tell us?
V Duranthon, P Chavatte‐Palmer - Molecular Reproduction and …, 2018 - Wiley Online Library
Early stages of mammalian embryonic development are now known to be very sensitive to
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …
[HTML][HTML] Metabolic-endocrine disruption due to preterm birth impacts growth, body composition, and neonatal outcome
LS Möllers, EI Yousuf, C Hamatschek, KM Morrison… - Pediatric …, 2022 - nature.com
Despite optimized nutrition, preterm-born infants grow slowly and tend to over-accrete body
fat. We hypothesize that the premature dissociation of the maternal–placental–fetal unit …
fat. We hypothesize that the premature dissociation of the maternal–placental–fetal unit …
[HTML][HTML] Genes and pathways associated with pregnancy loss in dairy cattle
Pregnancy loss directly impairs reproductive performance in dairy cattle. Here, we
investigated genetic factors associated with pregnancy loss following detection of a viable …
investigated genetic factors associated with pregnancy loss following detection of a viable …
[HTML][HTML] Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy
Q Li, A Sharkey, M Sheridan, E Magistrati… - Cell Stem Cell, 2024 - cell.com
In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is
critical for successful pregnancy. Evidence suggests that this process is regulated by uterine …
critical for successful pregnancy. Evidence suggests that this process is regulated by uterine …
Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids
C Zhao, S Biondic, K Vandal, ÅK Björklund… - Genome …, 2022 - genome.cshlp.org
The preconceptual, intrauterine, and early life environments can have a profound and long-
lasting impact on the developmental trajectories and health outcomes of the offspring. Given …
lasting impact on the developmental trajectories and health outcomes of the offspring. Given …