Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

The pathway to a thriving newborn begins before conception and continues in utero with a
healthy placenta and the right balance of nutrients and growth factors that are timed and …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

Early stages of mammalian embryonic development are now known to be very sensitive to
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …

Despite optimized nutrition, preterm-born infants grow slowly and tend to over-accrete body
fat. We hypothesize that the premature dissociation of the maternal–placental–fetal unit …

Pregnancy loss directly impairs reproductive performance in dairy cattle. Here, we
investigated genetic factors associated with pregnancy loss following detection of a viable …

In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is
critical for successful pregnancy. Evidence suggests that this process is regulated by uterine …

The preconceptual, intrauterine, and early life environments can have a profound and long-
lasting impact on the developmental trajectories and health outcomes of the offspring. Given …