The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

The heart and vascular system are susceptible to the harmful effects of alcohol. Alcohol is an
active toxin that undergoes widespread diffusion throughout the body, causing multiple …

Background & Aims Defects in lysosome function and autophagy contribute to the
pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol …

Loss of hepatic DRP1 exacerbates alcoholic hepatitis by indu... : Hepatology Loss of hepatic
DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial …

Many natural polysaccharides from bio-resources hold advantages of multi-functions, high
efficiency, non-toxicity or low side effect, and have strong potentials in protection against …

Alcoholic liver disease claims two million lives per year. We previously reported that
autophagy protected against alcohol-induced liver injury and steatosis by removing …

Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy
sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In …

Background & Aims Alcoholic steatohepatitis (ASH) is the progressive form of alcoholic liver
disease and may lead to cirrhosis and hepatocellular carcinoma. We studied mouse models …

Understanding the underlying molecular mechanisms of liver fibrosis is important to develop
effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in …

Alcoholic liver disease (ALD) is a major health problem in the United States and worldwide
without successful treatments. Chronic alcohol consumption can lead to ALD, which is …