RORα switches transcriptional mode of ERRγ that results in transcriptional repression of CYP2E1 under ethanol-exposure

YH Han, DK Kim, TY Na, NL Ka, HS Choi… - Nucleic Acids …, 2016 - academic.oup.com
Abstract Increased cytochrome P450 2E1 (CYP2E1) expression is the main cause of
oxidative stress, which exacerbates alcoholic liver diseases (ALDs). Estrogen-related …

[HTML][HTML] Impaired Rab7 and dynamin2 block fat turnover by autophagy in alcoholic fatty livers

Y Li, WX Ding - Hepatology communications, 2017 - journals.lww.com
Alcoholic liver disease (ALD) at early stages is characterized by hepatic steatosis, ie,
excessive accumulation of fat (eg, triglyceride or triacylglycerol, esterified cholesterol) …

Proteomic investigations of transcription factors critical in geniposide-mediated suppression of alcoholic steatosis and in overdose-induced hepatotoxicity on liver in …

J Wei, Q Man, C Ding, Y Hu, M Liu, H Li… - Journal of proteome …, 2019 - ACS Publications
Alcoholic steatosis is one of the most prevalent forms of liver disease, and appropriate
insight and application of anti-steatosis drugs must be considered. Geniposide, the major …

Molecular regulation of miRNAs and potential biomarkers in the progression of hepatic steatosis to NASH

Y Wang, Z Liu, W Zou, H Hong, H Fang… - Biomarkers in …, 2015 - Taylor & Francis
Increasing evidence suggests that microRNAs regulate diverse biological functions in the
liver and play a very important function in metabolic-related disorders such as nonalcoholic …

Preventive and therapeutic effects of pigment and polysaccharides in Lycium barbarum on alcohol-induced fatty liver disease in mice

D Li, L Sun, Y Yang, Z Wang, X Yang… - CyTA-Journal of Food, 2018 - Taylor & Francis
This study aims to explore the preventive and therapeutic effects of Lycium barbarum
pigment (LP) and polysaccharides (LBPs) on alcohol-induced fatty liver disease (AFLD) in …

Reduced methylation of PP2Ac promotes ethanol–induced lipid accumulation through FOXO1 phosphorylation in vitro and in vivo

Y Zhang, T Yuan, Z Su, X Wang, Y Wang, Y Ni, Y Zuo… - Toxicology Letters, 2020 - Elsevier
Although disturbance of the methionine cycle and sequent decrease in hepatic methylation
capacity are known to be important factors in the development of alcoholic liver injury, the …

Investigation of dysregulated lipid metabolism in diabetic mice via targeted metabolomics of bile acids in enterohepatic circulation

Y Ruan, R Liu, L Gong - Rapid Communications in Mass …, 2022 - Wiley Online Library
Rationale The mechanism of lipid metabolism disorder in type 2 diabetes (T2DM) remains
unclear. This study aimed to reveal the mechanism underlying dysregulated lipid …

[HTML][HTML] Venta de alcohol y tasa de enfermedad hepática alcohólica por departamentos en Colombia

V Andrade, JD Mosos, B Pacheco… - Revista colombiana de …, 2015 - scielo.org.co
Objetivos: determinar la asociación estadística entre el diagnóstico de enfermedad hepática
alcohólica según Registros Individuales de Prestaciones de Servicios de Salud (RIPS) y …

Diethylcarbamazine: Possible therapeutic alternative in the treatment of alcoholic liver disease in C57 BL/6 mice

GB Rodrigues, SWS Rocha, LAM Santos… - Clinical and …, 2015 - Wiley Online Library
Alcoholic liver disease is a major cause of chronic liver disease worldwide.
Diethylcarbamazine (DEC) is a drug that has anti‐inflammatory properties due to its effects …

[HTML][HTML] 白介素-22 在肝损伤中JAK-STAT3 通路作用的研究进展

岑瑜, 郭晓云, 姜海行 - 世界华人消化杂志, 2015 - wjgnet.com
Abstract 白介素-22 (interleukin-22, IL-22) 是IL-10 家族成员之一, 主要是由Th22
细胞分泌的细胞因子, 与特异性表达IL-22 受体的组织细胞相结合, 进而激活信号传导与转录激活 …