The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal
development and in leukemogenesis. Transcriptional activation of this gene through …

Gene-modified autologous hematopoietic stem cells (HSC) can provide ample clinical
benefits to subjects suffering from X-linked chronic granulomatous disease (X-CGD), a rare …

Purpose Acute myeloid leukemia (AML) with inv (3)(q21q26. 2)/t (3; 3)(q21; q26. 2)[inv (3)/t
(3; 3)] is recognized as a distinctive entity in the WHO classification. Risk assignment and …

We investigated the relative prognostic significance of cytogenetics in 635 adult acute
myeloid leukemia (AML) patients 60 years of age or older treated on front-line protocols …

The EVI1 gene, located in chromosomal band 3q26, is a transcription factor that has stem
cell-specific expression pattern and is essential for the regulation of self-renewal of …

Abstract Monosomy 7 (− 7) and deletion 7q\del (7q) are rare in childhood acute myeloid
leukemia (AML). We retrospectively collected data on 258 children with AML or refractory …

Stem cell gene therapy using the MFGS-gp91 phox retroviral vector was performed on a 27-
year-old patient with X-linked chronic granulomatous disease (X-CGD) in 2014. The …

Rearrangements of chromosome band 3q26. 2 lead to overexpression of the EVI1 gene and
are associated with a poor prognosis in myeloid malignancies. EVI1 is also overexpressed …

In contrast to the well‐documented involvement of EVI1 in various 3q26 aberrations, the
transcriptional status of EVI1 in rare recurrent or sporadic 3q26 chromosomal defects has …

Though reported from a wide variety of human neoplasias, ring chromosomes, in general,
are a rare finding in these diseases. The majority were detected by chance when tumors …