In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone,
suggesting that different mechanisms underlie age-associated bone loss in these 2 …

Significance Cellular growth arrest, associated with 'senescence', helps to safeguard against
the accumulation of DNA damage which is often recognized as the underlying mechanism of …

Doxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced
cognitive impairments (chemobrain). Chemobrain is associated with inflammation and …

Cellular senescence, a hallmark of ageing, contributes to tissue or organ dysfunction and
the pathophysiology of diverse age-related diseases (ARD) by various mechanisms …

Pharmacologically active compounds that manipulate cellular senescence (senotherapies)
have recently shown great promise in multiple pre-clinical disease models, and some of …

Senescence is a cellular state characterized by its near-permanent halted cell cycle and
distinct secretory phenotype. Although senescent cells have a variety of beneficial …

Senescent cells (SCs) accumulate with age and cause various age-related diseases.
Clearance of SCs by transgenic or pharmaceutical strategies has been demonstrated to …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

Highlights•Cellular senescence is the biological central mechanism for the major age-
related diseases.•A large number of molecules, including synthetic senolytic and natural …

Cellular senescence is a natural tumor suppression mechanism defined by a stable
proliferation arrest. In the context of cancer treatment, cancer cell therapy-induced …