Triple negative breast cancers (TNBC) present a poor prognosis primarily due to their
resistance to chemotherapy. This resistance is known to be associated with elevated …

Recent years have witnessed the rapid development of targeted protein degradation (TPD),
especially proteolysis targeting chimeras. These degraders have manifested many …

Proteolysis targeting chimeras (PROTACs) are bifunctional compounds that recruit an E3
ligase to a target protein to induce ubiquitination and degradation of the target. Rational …

The vast majority of currently marketed drugs rely on small molecules with an 'occupancy-
driven'mechanism of action (MOA). Therefore, the efficacy of these therapeutics depends on …

Introduction The anti-apoptotic BCL-2 family proteins, such as BCL-2, BCL-XL, and MCL-1,
are excellent cancer therapeutic targets. The FDA approval of BCL-2 selective inhibitor …

Unsatisfactory physicochemical properties of macromolecular drugs seriously hinder their
application in tumor immunotherapy. However, these problems can be effectively solved by …

Diabetic foot ulcers (DFUs) are a prevalent and profoundly debilitating complication that
afflicts individuals with diabetes mellitus (DM). These ulcers are associated with substantial …

Given its increasing prevalence, aging is of great concern to researchers worldwide. Cellular
senescence is a physiological or pathological cellular state caused by aging and a …

Cellular senescence is a fundamental aging mechanism that is currently the focus of
considerable interest as a pathway that could be targeted to ameliorate aging across …

Abstract BCL-X L is an anti-apoptotic protein that plays an important role in tumorigenesis,
metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-X L …