Cardiovascular risk-benefit profile of sibutramine
AJ Scheen - American Journal of Cardiovascular Drugs, 2010 - Springer
Sibutramine is a combined norepinephrine and serotonin reuptake inhibitor used as an
antiobesity agent to reduce appetite and promote weight loss in combination with diet and …
antiobesity agent to reduce appetite and promote weight loss in combination with diet and …
WITHDRAWN—a resource for withdrawn and discontinued drugs
VB Siramshetty, J Nickel, C Omieczynski… - Nucleic acids …, 2016 - academic.oup.com
Post-marketing drug withdrawals can be associated with various events, ranging from safety
issues such as reported deaths or severe side-effects, to a multitude of non-safety problems …
issues such as reported deaths or severe side-effects, to a multitude of non-safety problems …
Pharmacogenetics of drugs withdrawn from the market
W Zhang, MW Roederer, WQ Chen, L Fan… - …, 2012 - Taylor & Francis
The safety and efficacy of candidate compounds are critical factors during the development
of drugs, and most drugs have been withdrawn from the market owing to severe adverse …
of drugs, and most drugs have been withdrawn from the market owing to severe adverse …
Colorimetric and reverse fluorescence Dual-Signal Readout Immunochromatographic Assay for the sensitive determination of sibutramine
Y Gui, Y Zhao, P Liu, Y Wang, X Mao, C Peng… - ACS …, 2024 - ACS Publications
Later flow immunochromatographic assay has been widely used in clinical, environmental,
and other diagnostic applications owing to its high sensitivity and throughput. However, most …
and other diagnostic applications owing to its high sensitivity and throughput. However, most …
Drug treatment for obesity in the post-sibutramine era
BMY Cheung - Drug safety, 2011 - Springer
Obesity is a major health problem worldwide. It is associated with cardiovascular diseases,
diabetes mellitus and decreased longevity. In managing obesity, diet and exercise are …
diabetes mellitus and decreased longevity. In managing obesity, diet and exercise are …
Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species
Y Morikawa, A Shibata, N Okumura, A Ikari… - Toxicology and Applied …, 2017 - Elsevier
Overdose administration of sibutramine, a serotonin-noradrenalin reuptake inhibitor, is
considered to elicit severe side effects including hypertension, whose pathogenic …
considered to elicit severe side effects including hypertension, whose pathogenic …
Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: a crucial role for the CYP2B6* 6 allele
IC Hwang, JY Park, HY Ahn, KK Kim, HS Suh, KD Ko… - Clinica Chimica …, 2014 - Elsevier
Background Various cytochrome P450 isoforms modulate sibutramine activity and influence
sibutramine plasma levels and pharmacokinetics. However, there are no available data to …
sibutramine plasma levels and pharmacokinetics. However, there are no available data to …
Allele and genotype frequencies of CYP2B6 in a Turkish population
N Yuce-Artun, G Kose, HS Suzen - Molecular biology reports, 2014 - Springer
Increasing interest in cytochrome P450 2B6 (CYP2B6) genetic polymorphism was
stimulated by revelations of a specific CYP2B6 genotype significantly affecting the …
stimulated by revelations of a specific CYP2B6 genotype significantly affecting the …
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and …
R Nirogi, RC Palacharla, AR Mohammed… - Chemico-Biological …, 2015 - Elsevier
The objective of the study was to evaluate the metabolism dependent inhibition of CYP2B6
catalyzed bupropion hydroxylation in human liver microsomes by monoamine oxidase …
catalyzed bupropion hydroxylation in human liver microsomes by monoamine oxidase …
Simultaneous determination of sibutramine and its active metabolites in human plasma by LC‐MS/MS and its application to a pharmacokinetic study
JW Bae, CI Choi, CG Jang… - Biomedical …, 2011 - Wiley Online Library
ABSTRACT A simple and sensitive liquid chromatography–electrospray ionization–tandem
mass spectrometry (LC‐ESI‐MS/MS) technique was developed and validated for the …
mass spectrometry (LC‐ESI‐MS/MS) technique was developed and validated for the …