Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by
liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly …

The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …

Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …

The recent demonstration that primary cells from the liver can be expanded in vitro as
organoids holds enormous promise for regenerative medicine and disease modelling. The …

Tissue damage dramatically alters how cells interact with their microenvironment. These
changes in turn dictate cellular responses, such as stem cell activation, yet early cellular …

Proliferating ducts, termed “oval cells,” have long been thought to be bipotential, that is,
produce both biliary ducts and hepatocytes during chronic liver injury. The precursor to oval …

The liver is a highly regenerative organ, but its regenerative capacity is compromised in
severe liver diseases. Hepatocyte-driven liver regeneration that involves the proliferation of …