Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

The skin is the largest organ of the human body and the one mostly exposed to outdoor
contaminants. To evaluate the biological mechanisms underlying skin damage caused by …

Abstract Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have
gained substantial interest due to their specific structure and biological functions. Humans …

Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Cancer is a significant global public health issue and, despite advancements in detection
and treatment, the prognosis remains poor. Cancer is a complex disease characterized by …

Autophagy is a highly controlled lysosome-mediated function in eukaryotic cells to eliminate
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

Background & aims Despite advances in chemotherapeutic agents and surgical approaches
for its management, gastrointestinal cancer still accounts for 27% of new cancer cases and …