Randomized controlled trials (RCTs) are the gold‐standard for benefit–risk assessments
during drug approval processes. Real‐word data (RWD) and the resulting real‐world …

Objectives Patients undergoing surgery for severe aortic stenosis (SAS) can be treated with
either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement …

Importance Intravenous edaravone is approved as a disease-modifying drug for patients
with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to short-term …

Introduction The aim of this work is to evaluate baricitinib safety with respect to venous
thromboembolism (VTE), major adverse cardiovascular events (MACE), and serious …

Background In clinical medical research, causality is demonstrated by randomized
controlled trials (RCTs). Often, however, an RCT cannot be conducted for ethical reasons …

Abstract Background The production of IgE molecules specific to the carbohydrate galactose‐
α‐1, 3‐galactose (alpha‐gal) is known to induce delayed anaphylaxis against mammalian …

Aim To test the hypothesis that simultaneous mobile phone-based alerting of CPR-trained
volunteers (Mobile-Rescuers) with Emergency Medical Service (EMS) teams leads to better …

Background In recent years there has been an increasing, partially also critical interest in
understanding the potential benefits of generating real-world evidence (RWE) in medicine …

Background Several studies have suggested that short-course antibiotic therapy was
effective in Pseudomonas aeruginosa (PA) bloodstream infections (BSI) in …

Background Comparative effectiveness (CE) research allows real-world treatment
comparisons using outcome measurements important to physicians/patients. This German …