Our gut harbours trillions of microorganisms essential for the maintenance of homeostasis
and host physiology in health and disease. In the last decade, there has been a growing …

Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

In the past years, a significant volume of research has implicated the appetitive hormone
ghrelin in the mechanisms underlying drug use and addiction. From a neuroscientific …

Due to the limited efficacy of existing medications for addictive disorders including alcohol
use disorder (AUD), the need for additional medications is substantial. Potential new …

The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …

The orexigenic peptide ghrelin increases the release of dopamine in the nucleus
accumbens (NAc) shell via central ghrelin receptors, especially those located in the ventral …

Since its discovery, the gut hormone, ghrelin, has been implicated in diverse functional roles
in the central nervous system. Central and peripheral interactions between ghrelin and other …

There is a substantial need for new pharmacological treatments of addiction, and appetite-
regulatory peptides are implied as possible candidates. Appetite regulation is complex and …

Alcohol use disorder (AUD) is often described as repeated phases of binge drinking,
compulsive alcohol-taking, craving for alcohol during withdrawal, and drinking with an aim to …

Cocaine addiction is a significant medical and public concern. Despite decades of research
effort, development of pharmacotherapy for cocaine use disorder remains largely …