Statins and oral biofilm: Simvastatin as a promising drug to control periodontal dysbiosis

RD Parolina de Carvalho, J de Andrade Moreno… - Oral …, 2024 - Wiley Online Library
Objectives This study evaluated antimicrobial activity of atorvastatin, pravastatin,
rosuvastatin, and simvastatin against oral bacteria, and the interaction of simvastatin with …

Effect of Diclofenac and Simvastatin on Bone Defect Healing—An In Vivo Animal Study

T Karanikola, A Cheva, K Sarafidou… - Biomimetics, 2022 - mdpi.com
Non-steroidal, anti-inflammatory drugs and statins are two widely prescribed drug classes
that affect bone formation. The aim of this study was to elucidate the effect of diclofenac and …

The evaluation of cytotoxicity and cytokine IL-6 production of root canal sealers with and without the incorporation of simvastatin: an invitro study

A Sharma, K Sanjeev, VMJ Selvanathan, M Sekar… - BMC Oral Health, 2022 - Springer
Background Freshly mixed root canal sealers when proximate the periapical tissues, trigger
varying degrees of cytotoxicity/inflammatory reactions. Simvastatin, a class of the drug statin …

New insights on mode of action of vasorelaxant activity of simvastatin

K Verma, R Shukla, J Dwivedi, S Paliwal… - …, 2023 - Springer
Simvastatin is a semisynthetic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-
CoA) reductase and is used extensively to treat atherosclerotic cardiovascular disease …

Statins—Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers

MM Granat, J Eifler-Zydel, J Kolmas - International Journal of Molecular …, 2024 - mdpi.com
Statins, widely prescribed for lipid disorders, primarily target 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG-CoA) reductase competitively and reversibly, resulting in reduced low …

Role of oral health in heart and vascular health: A population-based study

AS Ghanem, O Németh, M Móré, AC Nagy - Plos one, 2024 - journals.plos.org
Background and aim Conditions such as hypertension, cardiovascular diseases, and
hypercholesterolemia, are a major public health challenge. This study investigates the …

Calcium-channel-blocker-influenced gingival enlargement: A conundrum demystified

P Tonsekar, V Tonsekar - Oral, 2021 - mdpi.com
The aim of the article is to discuss the development of calcium channel blocker (CCB)
influenced gingival enlargement. Data and Sources: MEDLINE/PubMed, Scopus …

Hispanic adults with type 2 diabetes mellitus using lipid-lowering agents have better periodontal health than non-users

OM Andriankaja, KJ Joshipura… - … in Chronic Disease, 2023 - journals.sagepub.com
Background: Recent studies suggest that lipid-lowering agents (LLA) may reduce chronic
periodontitis, but it is unknown whether this benefit extends to people with type 2 diabetes …

Enhancing Oral Bioavailability of Simvastatin Using Uncoated and Polymer-Coated Solid Lipid Nanoparticles

AE Abd-Elghany, O El-Garhy, AA Fatease, AH Alamri… - Pharmaceutics, 2024 - mdpi.com
Simvastatin (SVA) is a well-prescribed drug for treating cardiovascular and
hypercholesterolemia. Due to the extensive hepatic first-pass metabolism and poor …

[HTML][HTML] Evaluation of the Anti-microbial Efficacy of a Novel Endodontic Irrigant Against Enterococcus faecalis: An In Vitro Study

G Selvakumar, A Raveendran, B Swathika, S Ganesan… - Cureus, 2023 - ncbi.nlm.nih.gov
Introduction: Enterococcus faecalis is a constant microbiome that plays an inevitable role in
the etiology of peri radicular lesions after endodontic treatment, chronic and, apical …