Neurodegenerative diseases, particularly Alzheimer's disease (AD), pose a significant
challenge in ageing populations. Our current understanding indicates that the onset of toxic …

Current views on immunity support the idea that immunity extends beyond defense functions
and is tightly intertwined with several other fields of biology such as virology, microbiology …

Cerebrovascular pathology often co-exists with Alzheimer's disease pathology and can
contribute to Alzheimer's disease-related clinical progression. However, the degree to which …

The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research
agenda and clinical trial designs over the past decades, but precisely how amyloid-β …

Alzheimer's disease is defined by the presence of β-amyloid plaques and neurofibrillary tau
tangles potentially preceding clinical symptoms by many years. Previously only detectable …

Alzheimer's disease (AD) is the most common disorder associated with cognitive
impairment. Recent observations emphasize the pathogenic role of multiple factors inside …

Purpose Early-onset Alzheimer disease (EOAD) is rare, highly heterogeneous, and
associated with poor prognosis. This AT (N) Framework–based study aimed to compare …

Background: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-
onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and …

Abstract The A/T/N research framework has been proposed for the diagnosis and prognosis
of Alzheimer's disease (AD). However, the spatial distribution of ATN biomarkers and their …

Background Tau-specific positron emission tomography (tau-PET) holds promise in
distinguishing Alzheimer's disease (AD) and elucidating the spatial distribution of tau …