Background DNA damage response (DDR) defects imply genomic instability and favor
tumor progression but make the cells vulnerable to the pharmacological inhibition of the …

Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and
protein in the tissues of smokers. Not only are these biochemical events relevant to the …

A critical link exists between an individual's ability to repair cellular DNA damage and cancer
development, progression, and response to therapy. Knowledge gained about the proteins …

DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and
repair of smoking‐related DNA adducts remains particularly challenging as both smokers …

Why does a constant barrage of DNA damage lead to disease in some individuals, while
others remain healthy? This article surveys current work addressing the implications of inter …

BACKGROUND Patients with Fanconi anemia (FA) have an increased risk for head and
neck squamous cell carcinoma (HNSCC). The authors sought to determine the prevalence …

Proliferative verrucous leukoplakia (PVL) is a rare less recognized form of oral leukoplakia.
Patients with this condition represent a unique clinically and pathologically progressive …

Purpose Platinum-based regimens are the standard chemotherapy for patients with
advanced non–small-cell lung cancer (NSCLC). DNA repair capacity (DRC) in tumor cells …

The majority of conventional leukoplakia remains constant and only a subset progress to
high‐grade dysplasia or invasive carcinoma. A less recognized form known as proliferative …

Alteration of DNA integrity is a potential cause of cancer and it is assumed that reduced DNA
repair capacity and accumulation of DNA damage may represent intermediate markers in …