Rationale An increasingly compelling literature points to a major role for the glutamate
system in mediating the effects of alcohol on behavior and the pathophysiology of …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the
initiation and development of alcohol and drug dependence. Alcohol consumption induced …

Alcoholism is one of the most prevalent substance dependence disorders in the world.
Advances in research in the neurobiological mechanisms underlying alcohol dependence …

Risk for alcohol dependence in humans has substantial genetic contributions. Successful
rodent models generally attempt to address only selected features of the human diagnosis …

Recent evidence suggests that corticotropin-releasing factor (CRF) receptor (CRFR)
signaling is involved in modulating binge-like ethanol consumption in C57BL/6J mice. In this …

Background Alcohol increases the expression of Group 1 metabotropic glutamate receptors
(mG lu R s) and their associated scaffolding protein Homer2 and stimulates …

Abstract Rationale Fragile X syndrome (FXS) is an inherited form of developmental disability
and a single gene cause of autism. As a disorder with increasingly understood …

Alcohol dependence/addiction is mediated by complex neural mechanisms that involve
multiple brain circuits and neuroadaptive changes in a variety of neurotransmitter and …

Binge alcohol (ethanol) drinking is a destructive pattern of ethanol consumption that may
precipitate ethanol dependence—a chronic, debilitating, and prevalent health problem …