How and when should we monitor chimerism after allogeneic stem cell transplantation?

P Bader, D Niethammer, A Willasch… - Bone marrow …, 2005 - nature.com
Chimerism analysis has become an important tool for the peri-transplant surveillance of
engraftment. It offers the possibility to realize impending graft rejection and can serve as an …

Chimerism analysis for clinicians: a review of the literature and worldwide practices

AG Blouin, M Askar - Bone marrow transplantation, 2022 - nature.com
This review highlights literature pertinent to chimerism analysis in the context of
hematopoietic cell transplantation (HCT). We also conducted a survey of testing practices of …

[HTML][HTML] Standardizing definitions of hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell …

MA Kharfan-Dabaja, A Kumar, E Ayala, M Aljurf… - … and cellular therapy, 2021 - Elsevier
Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for certain
hematologic malignancies and nonmalignant diseases. The field of allo-HCT has witnessed …

Graft failure in the modern era of allogeneic hematopoietic SCT

R Olsson, M Remberger, M Schaffer… - Bone marrow …, 2013 - nature.com
Graft failure may contribute to increased morbidity and mortality after allogeneic
hematopoietic SCT (allo-HSCT). Here, we present risk factors for graft failure in all first allo …

Quantitative analysis of chimerism after allogeneic stem cell transplantation by real‐time polymerase chain reaction with single nucleotide polymorphisms, standard …

M Koldehoff, NK Steckel, M Hlinka… - American journal of …, 2006 - Wiley Online Library
We compared the results of chimerism analyses with real‐time SNP‐PCR to those obtained
by the classical STR‐PCR method in 135 hematopoietic stem cell transplantation recipients …

[HTML][HTML] Digital PCR to assess hematopoietic chimerism after allogeneic stem cell transplantation

T Stahl, MU Böhme, N Kröger, B Fehse - Experimental hematology, 2015 - Elsevier
Analysis of hematopoietic chimerism after allogeneic stem cell transplantation represents a
crucial method to evaluate donor-cell engraftment. Whereas sensitivity of classical …

[HTML][HTML] Mixed T lymphocyte chimerism after allogeneic hematopoietic transplantation is predictive for relapse of acute myeloid leukemia and myelodysplastic …

HC Lee, RM Saliba, G Rondon, J Chen… - Biology of Blood and …, 2015 - Elsevier
Chimerism testing after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in
patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) …

[HTML][HTML] High alloreactivity of low-dose prophylactic donor lymphocyte infusion in patients with acute leukemia undergoing allogeneic hematopoietic cell …

M Liga, E Triantafyllou, M Tiniakou… - Biology of Blood and …, 2013 - Elsevier
The value of prophylactic donor lymphocyte infusion (pDLI) is unclear and differs among
diseases and transplantation protocols. Experience with this approach in patients with acute …

Diagnostic value of highly-sensitive chimerism analysis after allogeneic stem cell transplantation

L Sellmann, K Rabe, I Bünting, E Dammann… - Bone marrow …, 2018 - nature.com
Conventional analysis of host chimerism (HC) frequently fails to detect relapse before its
clinical manifestation in patients with hematological malignancies after allogeneic stem cell …

[HTML][HTML] Comparison of chimerism and minimal residual disease monitoring for relapse prediction after allogeneic stem cell transplantation for adult acute …

TH Terwey, PG Hemmati, M Nagy, H Pfeifer… - Biology of Blood and …, 2014 - Elsevier
Little data are available on the relative merits of chimerism and minimal residual disease
(MRD) monitoring for relapse prediction after allogeneic hematopoietic stem cell …