Reliable quantification of hematopoietic chimerism after allogeneic transplantation for acute leukemia using amplification by real-time PCR of null alleles and insertion …

A Jimenez-Velasco, M Barrios, J Roman-Gomez… - Leukemia, 2005 - nature.com
Increasing mixed chimerism (MC) after allogeneic stem cell transplantation (SCT) has been
associated with a high risk of relapse in acute leukemia. We evaluated a new method for …

Chimerism analysis in peripheral blood using indel quantitative real-time PCR is a useful tool to predict post-transplant relapse in acute leukemia

N Jacque, S Nguyen, JL Golmard, M Uzunov… - Bone marrow …, 2015 - nature.com
Detection of increasing mixed chimerism (IMC) using standard PCR correlates with relapse
after allo-SCT for acute leukemias (ALs). Quantitative real-time PCR of insertion/deletion …

[HTML][HTML] Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia

C Huisman, RA De Weger, L De Vries… - Bone marrow …, 2007 - nature.com
The role of chimerism analysis as a prognostic indicator of relapse after hematopoietic stem
cell transplantation (SCT) is controversial. We monitored chimerism status by short tandem …

[HTML][HTML] Earlier relapse detection after allogeneic haematopoietic stem cell transplantation by chimerism assays: digital PCR versus quantitative real-time PCR of …

J Valero-Garcia, MDC González-Espinosa, M Barrios… - PLoS …, 2019 - journals.plos.org
Background The analysis of molecular haematopoietic chimerisms (HC) has become a well-
established method to monitor the transplant evolution and to assess the risk of relapse after …

Emerging approaches to improve allogeneic hematopoietic cell transplantation outcomes for nonmalignant diseases

Z DeFilipp, M Hefazi, YB Chen… - Blood, The Journal of …, 2022 - ashpublications.org
Many congenital or acquired nonmalignant diseases (NMDs) of the hematopoietic system
can be potentially cured by allogeneic hematopoietic cell transplantation (HCT) with varying …

[HTML][HTML] NCI first international workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the …

N Kröger, U Bacher, P Bader, S Böttcher… - Biology of Blood and …, 2010 - Elsevier
Relapse has become the major cause of treatment failure after allogeneic stem cell
transplantation. Outcome of patients with clinical relapse after transplantation generally …

Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation

C Thiede, M Bornhäuser, G Ehninger - Acta haematologica, 2004 - karger.com
Abstract Analysis of donor chimerism has become a routine method for the documentation of
engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). In recent years …

Diagnostic chimerism analysis after allogeneic stem cell transplantation: new methods and markers

C Thiede - American Journal of Pharmacogenomics, 2004 - Springer
Abstract Analysis of chimerism after allogeneic hematopoietic cell transplantation is
important for assessing engraftment and the early detection of graft failure. In addition, the …

[HTML][HTML] Personalized chimerism test that uses selection of short tandem repeat or quantitative PCR depending on patient's chimerism status

J Tyler, L Kumer, C Fisher, H Casey, H Shike - The Journal of Molecular …, 2019 - Elsevier
Chimerism testing is used to monitor engraftment and risk of relapse after allogeneic
hematopoietic stem cell transplantation for hematologic malignancies. Although short …

[HTML][HTML] Allogeneic transplantation for pediatric acute lymphoblastic leukemia: the emerging role of peritransplantation minimal residual disease/chimerism monitoring …

MA Pulsipher, P Bader, T Klingebiel… - Biology of Blood and …, 2009 - Elsevier
Although improved donor sources and supportive care have decreased transplantation-
related mortality over the past decade, relapse remains the principal cause of failure after …