Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and
neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of …

Selective macroautophagy is an important protective mechanism against diverse cellular
stresses. In contrast to the well-characterized starvation-induced autophagy, the regulation …

Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …

A comprehensive genetics-based precision medicine strategy to selectively and
permanently inactivate only mutant, not normal allele, could benefit many dominantly …

In recent years, the inter-relationship between the innate immune system and the central
nervous system (CNS) has moved to the forefront of biomedical research, with the discovery …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …