Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

Gastrointestinal cancer is a leading cause of cancer-related mortality and remains a major
challenge for cancer treatment. Despite the combined administration of modern surgical …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Background Immunotherapy has evolved as a critical option to treat diverse cancers. The
active response to immunotherapy relies on the unique interaction between cancer and the …

The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune
responses, playing a crucial role in improving antitumor immunity through immune effector …

Immune checkpoints (ICs) have pivotal roles in regulating immune responses. The inhibitory
ICs in the tumor microenvironment (TME) have been implicated in the immune evasion of …

Gastrointestinal (GI) cancers represent a major public health problem worldwide. Due to the
late detection and high heterogeneity of GI cancers, traditional treatments, including surgery …

CD8+ lymphocytes are adaptive immunity cells with the particular function to directly kill the
target cell following antigen recognition in the context of MHC class I. In addition, CD8+ T …

TIGIT is a lymphocyte surface receptor, which is mainly expressed on the surface of CD8+ T
cells. The role of TIGIT in colorectal cancer and its expression pattern in colorectal cancer …

Introduction: LAG-3 is an inhibitory immune checkpoint molecule that suppresses T cell
activation and inflammatory cytokine secretion. T cell density in the tumor microenvironment …