[HTML][HTML] Reprogramming neurons for regeneration: The fountain of youth
Neurons in the central nervous system (CNS) are terminally differentiated cells that
gradually lose their ability to support regeneration during maturation due to changes in …
gradually lose their ability to support regeneration during maturation due to changes in …
[HTML][HTML] Therapeutic potential of PTB inhibition through converting glial cells to neurons in the brain
XD Fu, WC Mobley - Annual review of neuroscience, 2023 - annualreviews.org
Cell replacement therapy represents a promising approach for treating neurodegenerative
diseases. Contrary to the common addition strategy to generate new neurons from glia by …
diseases. Contrary to the common addition strategy to generate new neurons from glia by …
Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson's disease
W Chen, Q Zheng, Q Huang, S Ma, M Li - Elife, 2022 - elifesciences.org
Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …
[HTML][HTML] Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina
Direct reprogramming of glia into neurons is a potentially promising approach for the
replacement of neurons lost to injury or neurodegenerative disorders. Knockdown of the …
replacement of neurons lost to injury or neurodegenerative disorders. Knockdown of the …
[HTML][HTML] Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
Direct reprogramming of retinal Müller glia is a promising avenue for replacing
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …
[HTML][HTML] New AAV tools fail to detect Neurod1-mediated neuronal conversion of Müller glia and astrocytes in vivo
Background Reprogramming resident glial cells to convert them into neurons in vivo
represents a potential therapeutic strategy that could replenish lost neurons, repair …
represents a potential therapeutic strategy that could replenish lost neurons, repair …
[HTML][HTML] Molecular camouflage by a context-specific hydrogel as the key to unlock the potential of viral vector gene therapy
Gene therapy offers hope for currently untreatable diseases; the patient's own cellular
machinery is recruited to create therapeutics. However, unpredictable responses that lead to …
machinery is recruited to create therapeutics. However, unpredictable responses that lead to …
Reprogramming glial cells into functional neurons for neuro-regeneration: challenges and promise
F Wang, L Cheng, X Zhang - Neuroscience bulletin, 2021 - Springer
The capacity for neurogenesis in the adult mammalian brain is extremely limited and highly
restricted to a few regions, which greatly hampers neuronal regeneration and functional …
restricted to a few regions, which greatly hampers neuronal regeneration and functional …
Glycogen synthase kinase 3 signaling in neural regeneration in vivo
Abstract Glycogen synthase kinase 3 (GSK3) signaling plays important and broad roles in
regulating neural development in vitro and in vivo. Here, we reviewed recent findings of …
regulating neural development in vitro and in vivo. Here, we reviewed recent findings of …
[HTML][HTML] Zebrafish models of photoreceptor dysfunction and degeneration
NCL Noel, IM MacDonald, WT Allison - Biomolecules, 2021 - mdpi.com
Zebrafish are an instrumental system for the generation of photoreceptor degeneration
models, which can be utilized to determine underlying causes of photoreceptor dysfunction …
models, which can be utilized to determine underlying causes of photoreceptor dysfunction …