BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Lung cancer is the leading cause of cancer death worldwide. Cisplatin is the major DNA-
Damaging anticancer drug that cross-links the DNA in cancer cells, but many patients …

Summary Abnormal Uterine Bleeding (AUB) is a common debilitating condition that
significantly reduces quality of life of women across the reproductive age span. AUB creates …

Much more is known about hormonal than about non-hormonal signaling in uterine fibroids.
Growth factors, early life exposure and inflammation are key factors in uterine fibroid biology …

Cancer is still considered a “hopeless case”, which seriously endangers human health.
Therefore, it is of great significance to research and develop novel anticancer drugs. Active …

Photoreceptor cell death can cause progressive and irreversible visual impairments. Still,
effective therapies on retinal neuroprotection are not available. Hypoxia-inducible factors …

The small-molecule alkaloid halofuginone (HF) is obtained from febrifugine. Recent studies
on HF have aroused widespread attention owing to its universal range of noteworthy …

Multiple in vivo animal models for uterine leiomyoma do not adequately represent human
disease based on etiology, molecular phenotype, or limited fixed life span. Our objective …

The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine
leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL …