The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …

A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

The endolysosome system plays central roles in both autophagic degradation and secretory
pathways, including the release of extracellular vesicles and particles (EVPs). Although …

SARS-CoV-2 evolution threatens vaccine-and natural infection–derived immunity and the
efficacy of therapeutic antibodies. To improve public health preparedness, we sought to …

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …