COVID‐19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps

L Borges, TC Pithon-Curi, R Curi… - Mediators of …, 2020 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19) is a virus‐induced respiratory disease that may
progress to acute respiratory distress syndrome (ARDS) and is triggered by …

[HTML][HTML] Chemokines and chemokine receptors during COVID-19 infection

BA Khalil, NM Elemam, AA Maghazachi - Computational and structural …, 2021 - Elsevier
Chemokines are crucial inflammatory mediators needed during an immune response to
clear pathogens. However, their excessive release is the main cause of hyperinflammation …

Excessive neutrophils and neutrophil extracellular traps in COVID-19

J Wang, Q Li, Y Yin, Y Zhang, Y Cao, X Lin… - Frontiers in …, 2020 - frontiersin.org
Background: Cases of excessive neutrophil counts in the blood in severe coronavirus
disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was …

Neutrophil extracellular traps (NETs) and damage‐associated molecular patterns (DAMPs): two potential targets for COVID‐19 treatment

S Cicco, G Cicco, V Racanelli… - Mediators of …, 2020 - Wiley Online Library
COVID‐19 is a pandemic disease caused by the new coronavirus SARS‐CoV‐2 that mostly
affects the respiratory system. The consequent inflammation is not able to clear viruses. The …

[HTML][HTML] Tuberculosis and lung damage: from epidemiology to pathophysiology

S Ravimohan, H Kornfeld, D Weissman… - European respiratory …, 2018 - Eur Respiratory Soc
A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

[HTML][HTML] Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection

JM Adrover, L Carrau, J Daßler-Plenker, Y Bram… - JCI insight, 2022 - ncbi.nlm.nih.gov
Severe acute lung injury has few treatment options and a high mortality rate. Upon injury,
neutrophils infiltrate the lungs and form neutrophil extracellular traps (NETs), damaging the …

[HTML][HTML] Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury

E Lefrançais, B Mallavia, H Zhuo, CS Calfee… - JCI insight, 2018 - ncbi.nlm.nih.gov
Neutrophils dominate the early immune response in pathogen-induced acute lung injury, but
efforts to harness their responses have not led to therapeutic advancements. Neutrophil …

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

DN Douda, MA Khan, H Grasemann… - Proceedings of the …, 2015 - National Acad Sciences
Neutrophils cast neutrophil extracellular traps (NETs) to defend the host against invading
pathogens. Although effective against microbial pathogens, a growing body of literature now …

[HTML][HTML] Epithelial barrier dysfunction in chronic respiratory diseases

FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

M Toussaint, DJ Jackson, D Swieboda, A Guedán… - Nature medicine, 2017 - nature.com
Respiratory viral infections represent the most common cause of allergic asthma
exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma …