Schistosome infection is a major cause of global morbidity, particularly in sub-Saharan
Africa. However, there is no effective vaccine for this major neglected tropical disease, and …

Publisher Summary Schistosomes can be established in the mammalian host; cercariae
must penetrate the skin, transform into schistosomula, locate their favored site in the …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

The segregation of IgG2a and IgG1 immunoglobulin isotypes as markers for Th1 and Th2
lymphocytes respectively, was investigated in mice exposed to normal or optimally …

Significant quantities of PGE 2 were produced by cercariae of Schistosoma mansoni
following incubation with linoleic acid, a free fatty acid found on the surface of the skin …

Background Among more than 20,000 species of hermaphroditic trematodes,
Schistosomatidae are unusual since they have evolved gonochorism. In schistosomes, sex …

Schistosomiasis is a parasitic disease affecting over 200 million people in multiple organs,
including the lungs. Despite this, there is little understanding of pulmonary immune …

Schistosomes infect the mammalian host by direct penetration of the skin and must then
undergo a protracted migration to the site of parasitization, for Schistosoma mansoni the …

The laboratory mouse has been widely used to test the efficacy of schistosome vaccines and
a long list of candidates has emerged from this work, many of them abundant internal …

Schistosoma mansoni lung-stage larvae are known to be the major target of innate and
acquired immunity to schistosomiasis. Lung schistosomula cytosolic or surface membrane …