Managing chronic neuropathic pain: recent advances and new challenges

N Hange, S Poudel, S Ozair, T Paul… - Neurology Research …, 2022 - Wiley Online Library
Aim. Neuropathic pain affects 7–10% of the population, with most of the patients receiving
inadequate and incomplete treatment. Owing to the high financial burden and the poor …

Saffron (Crocus sativus) and its constituents for pain management: A review of current evidence

AM Pourbagher‐Shahri… - Phytotherapy Research, 2023 - Wiley Online Library
Pain can become a chronic and deliberating experience with a significant burden. In
preclinical and clinical studies, Saffron (Crocus sativus L.) has shown analgesic activities …

[HTML][HTML] Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of …

K Miyano, M Ikehata, K Ohshima, Y Yoshida, Y Nose… - PLoS …, 2022 - journals.plos.org
Mesenchymal stem cells (MSCs), which are isolated from adipose tissue (AD-MSCs),
umbilical cord (UC-MSCs), or bone marrow, have therapeutic potential including anti …

Chemogenetics modulation of electroacupuncture analgesia in mice spared nerve injury-induced neuropathic pain through TRPV1 signaling pathway

IH Hsiao, CM Yen, HC Hsu, HY Liao… - International Journal of …, 2024 - mdpi.com
Neuropathic pain, which is initiated by a malfunction of the somatosensory cortex system,
elicits inflammation and simultaneously activates glial cells that initiate neuroinflammation …

Cell therapy for neuropathic pain

QH Yin, TH Zou, SJ Sun, D Yang - Frontiers in Molecular …, 2023 - frontiersin.org
Neuropathic pain (NP) is caused by a lesion or a condition that affects the somatosensory
system. Pathophysiologically, NP can be ascribed to peripheral and central sensitization …

Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in …

ALL Oliveira, GGL Santos… - Stem cells …, 2021 - Wiley Online Library
Painful neuropathy is a common adverse effect of oxaliplatin (OXL), a platinum‐derivative
chemotherapeutic agent. Oxidative stress and mitochondrial dysfunction are key factors …

Different mechanisms guide the antinociceptive effect of bone marrow-mononuclear cells and bone marrow-mesenchymal stem/stromal cells in trigeminal neuralgia

CMM Costa, DS Santos, LCF Opretzka… - Life Sciences, 2024 - Elsevier
Aims Trigeminal neuralgia (TN) is a type of chronic orofacial pain evoked by trivial stimuli
that manifests as episodes of excruciating and sudden, recurrent paroxysmal pain. Most …

Intravenous application of human umbilical cord mesenchymal stem cells alleviate neuropathic pain by suppressing microglia activation in rats

X Xu, H Chen, Y Qiu, Y Chen, J Liu, B Zeng, L Lin… - Heliyon, 2024 - cell.com
Objective Neuropathic pain has been considered as one of the most serious chronic pain
subtypes and causes intolerable suffering to patients physically and mentally. This study …

Regenerative medicine for neuropathic pain: physiology, ultrasound and therapies with a focus on alpha-2-macroglobulin

JC Castro, D Wang, GCC Chien - Pain Management, 2022 - Taylor & Francis
The currently available drugs to treat neuropathic pain do not provide adequate pain
management. As such, other treatments including stem cells, platelet-rich plasma and …

Analgesic effect of apricot kernel oil on neuropathic pain in rats

M Akaberi, F Forouzanfar, H Rakhshandeh… - Heliyon, 2024 - cell.com
Background A somatosensory nerve lesion or disease causes neuropathic pain. Presently,
prescribed treatments are unsatisfactory or ineffective. The kernel oil of the apricot tree …