Importance Nucleic acid damage from oxidative stress (NA-OXS) may be a molecular
mechanism driving the severely increased morbidity and mortality from somatic causes in …

Background: Increasing evidence suggests that the presence of oxidative stress and
disorders of the antioxidant defense system are involved in a wide range of neuropsychiatric …

Objective Oxidative DNA damage has been associated with the pathophysiology of bipolar
disorder (BD) as one of the common pathways between increased medical comorbidity and …

Background Low-grade inflammation and oxidative stress have been implicated as potential
pathophysiological processes in bipolar disorder, but the underlying mechanism is …

Previous evidence suggests elevated levels of oxidatively-induced DNA damage,
particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8 …

Excessive oxidative stress-generated nucleoside damage seems to play a key role in
bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and …

Objectives Increased oxidative stress generated nucleoside damage seems to play a crucial
role in bipolar disorder (BD) pathophysiology. It may contribute to accelerated ageing and …

Chromatographic techniques have found wide application in the quantitative analysis of
modified deoxynucleosides in DNA and biological fluids, which is also reflected in clinical …

Enhanced oxidative stress-generated nucleoside damage may contribute to the increased
cardiovascular disease mortality in patients with bipolar disorder (BD) but the association …

Oxidative stress generated nucleoside damage seems to represent key pathophysiological
mechanisms of bipolar disorder (BD). Likewise, mood and activity are core features of BD …