Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

This paper is an interdisciplinary narrative review of efficacious non-invasive therapies that
are increasingly used to restore function in people with chronic spinal cord injuries (SCI) …

Rehabilitative treatment, including treadmill training, is considered an important strategy for
restoring motor function after spinal cord injury (SCI). However, many unexplained problems …

Cell transplantation therapy using human induced pluripotent stem cell-derived neural
stem/progenitor cells (hiPSC-NS/PCs) has attracted attention as a regenerative therapy for …

The translation of new therapies for spinal cord injury to clinical trials can be facilitated with
large animal models close in morpho-physiological scale to humans. Here, we report …

Rationale: Spinal cord injury (SCI) results in neural tissue damage. However, the limited
regenerative capacity of adult mammals' axons upon SCI leads to persistent neurological …

The transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced
pluripotent stem cells (hiPSCs) has shown promise in spinal cord injury (SCI) model …

Humans, primates, and rodents with cervical spinal cord injury (SCI) show permanent
sensorimotor dysfunction of the upper/forelimb as consequence of axonal damage and local …

Neuropathic pain often accompanies the functional deficits associated with spinal cord injury
(SCI) and further reduces a patient's quality of life. Clinical and pre-clinical research is …

Recent findings from multimodal imaging studies point to macrostructural pathological
changes in areas significantly distant from the epicenter of spinal cord injury, both in the …