Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape
HT Greinix, F Ayuk, R Zeiser - Leukemia, 2022 - nature.com
Patients with steroid-refractory graft-versus-host disease (GvHD) are known to have a poor
prognosis and for decades no approved drug has been available to treat this serious …
prognosis and for decades no approved drug has been available to treat this serious …
The role of myeloid-derived suppressor cells (MDSCs) in graft-versus-host disease (GVHD)
C Demosthenous, I Sakellari, V Douka… - Journal of clinical …, 2021 - mdpi.com
Background: Myeloid-derived suppressor cells (MDSCs) are implicated in the complex
interplay involving graft-versus-leukemia (GVL) effects and graft-versus-host disease …
interplay involving graft-versus-leukemia (GVL) effects and graft-versus-host disease …
Mesenchymal stromal cells plus basiliximab improve the response of steroid-refractory acute graft-versus-host disease as a second-line therapy: a multicentre …
H Fu, X Sun, R Lin, Y Wang, L Xuan, H Yao, Y Zhang… - BMC medicine, 2024 - Springer
Background For patients with steroid-refractory acute graft-versus-host disease (SR-
aGVHD), effective second-line regimens are urgently needed. Mesenchymal stromal cells …
aGVHD), effective second-line regimens are urgently needed. Mesenchymal stromal cells …
Hematopoietic cell transplantation, version 2.2020, NCCN clinical practice guidelines in oncology
Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor
cells into patients with hematologic disorders with the goal of re-establishing normal …
cells into patients with hematologic disorders with the goal of re-establishing normal …
Randomized phase II trial of extracorporeal phototherapy and steroids vs. steroids alone for newly diagnosed acute GVHD
RS Mehta, R Bassett, G Rondon, BJ Overman… - Bone marrow …, 2021 - nature.com
Steroids remain the initial therapy for acute graft-vs.-host disease (AGVHD). Strategies to
improve response and minimize steroid exposure are needed. We report results of a …
improve response and minimize steroid exposure are needed. We report results of a …
A new era in endothelial injury syndromes: toxicity of CAR-T cells and the role of immunity
E Gavriilaki, I Sakellari, M Gavriilaki… - International Journal of …, 2020 - mdpi.com
Immunotherapy with chimeric antigen receptor T (CAR-T cells) has been recently approved
for patients with relapsed/refractory B-lymphoproliferative neoplasms. Along with great …
for patients with relapsed/refractory B-lymphoproliferative neoplasms. Along with great …
Understanding and treatment of cutaneous graft-versus-host-disease
J Hong, J Fraebel, Y Yang, E Tkacyk, C Kitko… - Bone Marrow …, 2023 - nature.com
The skin is the outermost mechanical barrier where dynamic immune reactions take place
and is the most commonly affected site in both acute and chronic graft-versus-host disease …
and is the most commonly affected site in both acute and chronic graft-versus-host disease …
Molecular advances in sinusoidal obstruction syndrome/Veno-occlusive disease
I Mavrikou, D Chatzidimitriou, L Skoura… - International Journal of …, 2023 - mdpi.com
Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) detected in the liver
has been considered a severe complication of hematopoietic stem cell transplantation …
has been considered a severe complication of hematopoietic stem cell transplantation …
Ruxolitinib plus extracorporeal photopheresis (ECP) for steroid refractory acute graft-versus-host disease of lower GI-tract after allogeneic stem cell transplantation …
F Modemann, F Ayuk, C Wolschke… - Bone Marrow …, 2020 - nature.com
Acute graft-versus-host disease (aGVHD) is a serious complication after stem cell
transplantation and is associated with high non-relapse mortality. If steroid treatment as first …
transplantation and is associated with high non-relapse mortality. If steroid treatment as first …
Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers
Haematopoietic stem cell transplantation (HSCT) is the treatment of choice for malignant
haematological diseases. Despite continuous improvements in pre-and post-transplantation …
haematological diseases. Despite continuous improvements in pre-and post-transplantation …