The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies
R Bai, Y Li, L Jian, Y Yang, L Zhao, M Wei - Molecular Cancer, 2022 - Springer
Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …
Nonsense-mediated RNA decay: an emerging modulator of malignancy
K Tan, DG Stupack, MF Wilkinson - Nature Reviews Cancer, 2022 - nature.com
Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
J Dornhof, J Kieninger, H Muralidharan, J Maurer… - Lab on a Chip, 2022 - pubs.rsc.org
Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …
models for a more efficient and individualized cancer therapy. Currently, culture conditions …
[HTML][HTML] Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis
K Saxena, MK Jolly, K Balamurugan - Translational oncology, 2020 - Elsevier
Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …
Cancer stem cell plasticity–a deadly deal
AP Thankamony, K Saxena, R Murali… - Frontiers in molecular …, 2020 - frontiersin.org
Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …
Endothelial dysfunction driven by hypoxia—the influence of oxygen deficiency on NO bioavailability
A Janaszak-Jasiecka, A Siekierzycka, A Płoska… - Biomolecules, 2021 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …
The interactions of docetaxel with tumor microenvironment
R Gupta, MM Kadhim, AT Jalil, MQ Alasheqi… - International …, 2023 - Elsevier
There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …
response of cancer cells to therapy. There are also a large number of cells and secretions in …
Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia
S Bartoszewska, JF Collawn - Cellular & molecular biology letters, 2020 - Springer
During hypoxic conditions, cells undergo critical adaptive responses that include the up-
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …
Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration
Y Mikami, BR Grubb, TD Rogers, H Dang… - Science translational …, 2023 - science.org
Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than
the vasculature. Many pulmonary diseases are associated with intraluminal airway …
the vasculature. Many pulmonary diseases are associated with intraluminal airway …
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach
AN Chamseddine, T Assi, O Mir, S Chouaib - Pharmacology & therapeutics, 2022 - Elsevier
Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …