Microglia are considered to be the resident macrophages of the CNS and main effector of
immune brain function. Due to their essential role in the regulation of neuroinflammatory …

Immune privilege (IP), a term introduced to explain the unpredicted acceptance of allogeneic
grafts by the eye and the brain, is considered a unique property of these tissues. However …

3K3A-Activated Protein C (APC) is a recombinant variant of the physiological anticoagulant
APC with pleiotropic cytoprotective properties albeit without the bleeding risks. The anti …

Purpose: To describe the development of uveitis and retinal vasculitis in association with
pembrolizumab treatment for metastatic uveal melanoma. Methods: A case report and a brief …

Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized
by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible …

Introduction: 4-1BB (CD137) is an important T-cell stimulating molecule. The 4-1BB mAb or
its variants have shown remarkable therapeutic activity against autoimmunity, viral …

Therapeutic breakthroughs in a number of retinal degenerative diseases have come about
through the development of biotherapeutics administered directly into the eye. As a …

Undifferentiated uveitis (intraocular inflammation, IOI) is an idiopathic sight-threatening,
presumed autoimmune disease, accountable for~ 10% of all blindness in the developed …

Restoration of immunological tolerance to self antigens has been a major drive in
understanding the mechanisms of, and developing new treatments for, autoimmune and …

Background Uveitis is a potentially sight-threatening form of ocular inflammation that affects
the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited …