Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Abstract Background Long non-coding RNAs (lncRNAs) have drawn increasing attention
because they play a pivotal role in various types of autoimmune diseases, including …

Sialyltransferases transfer sialic acid to nascent oligosaccharides and are upregulated in
cancer. The inhibition of sialyltransferases is emerging as a potential strategy to prevent …

The characteristics that grant the most malignancy to cancer cells are the ability to evade
apoptotic mechanisms and the capacity to migrate beyond the boundaries of the original …

Like almost all cancer types, timely diagnosis is needed for leukemias to be effectively
cured. Drug efflux, attenuated drug uptake, altered drug metabolism, and epigenetic …

In this review, the sugar portions of glycoproteins, glycolipids, and glycosaminoglycans
constitute the glycome, and the genes involved in their biosynthesis, degradation, transport …

Aberrant glycosylation is a featured characteristic of cancer and plays a role in cancer
pathology; thus an understanding of the compositions and functions of glycans is critical for …

Cancers are the leading cause of death, causing around 10 million deaths annually by
2020. The most common cancers are those affecting the breast, lungs, colon, and rectum …

Long noncoding RNAs (lncRNAs) have emerged as important regulators of cancer
progression. Abnormal sialylation leads to renal cell carcinoma (RCC) malignancy …