Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

The liver is one of the most studied organs of the human body owing to its central role in
xenobiotic and drug metabolism. In recent decades, extensive research has aimed at …

The availability of an autologous transplantable auxiliary liver would dramatically affect the
treatment of liver disease. Assembly and function in vivo of a bioengineered human liver …

Mitochondrial damage is the major factor underlying drug-induced liver disease but whether
conditions that thwart mitochondrial injury can prevent or reverse drug-induced liver damage …

Exploring the cell biology of hepatocytes in vitro could be a powerful strategy to dissect the
molecular mechanisms underlying the structure and function of the liver in vivo. However …

Many tissues in the human body are composed of densely-packed cells and minimal
extracellular matrix (ECM). The resulting close cell proximity is important to retain cell …

Hepatocytes are epithelial cells with highly specialized polarity. The disorder and loss of
hepatocyte polarity leads to a weakness of cell adhesion and connection, the induction of …

Primary liver cancer (PLC) represents a significant proportion of all human cancers and
constitutes a substantial health and economic burden to society. Traditional therapeutic …

Liver resection causes marked perfusion alterations in the liver remnant both on the organ
scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level) …

Functional tissue architecture originates by self-assembly of distinct cell types, following
tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was …