Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …

Abstract Interleukin-6 (IL-6) is one of the most important inflammatory cytokines. IL-6 is
unique in signaling via a membrane bound and a soluble receptor. Intriguingly, these two …

The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to
unravel structure, function and regulation of protease expression, maturation and activity. In …

Highlights•IL-6 has pro-inflammatory and anti-inflammatory activities.•IL-6 is involved in
many autoimmune diseases.•IL-6 trans-signaling via the soluble IL-6 receptor is mainly pro …

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently
available to prevent it or to promote kidney repair after injury. Animal models demonstrate …

Rationale: Renal fibrosis is the terminal manifestation of chronic and irreversible renal
disease. Effective therapies other than dialysis are extremely limited. In this study, we …

Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …