Nootropic and anti-Alzheimer's actions of medicinal plants: molecular insight into therapeutic potential to alleviate Alzheimer's neuropathology

MS Uddin, A Al Mamun, MT Kabir, M Jakaria… - Molecular …, 2019 - Springer
Medicinal plants are the backbone of modern medicine. In recent times, there is a great urge
to discover nootropic medicinal plants to reverse cognitive dysfunction owing to their less …

Chemistry, biosynthesis and pharmacology of sarsasapogenin: a potential natural steroid molecule for new drug design, development and therapy

NH Mustafa, M Sekar, S Fuloria, MY Begum, SH Gan… - Molecules, 2022 - mdpi.com
Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from
Anemarrhena asphodeloides Bunge. Among the various phytosteroids present …

The genus Anemarrhena Bunge: a review on ethnopharmacology, phytochemistry and pharmacology

Y Wang, Y Dan, D Yang, Y Hu, L Zhang… - Journal of …, 2014 - Elsevier
Abstract Ethnopharmacological relevance Anemarrhena asphodeloides
Bunge.(Asparagaceae) yields Anemarrhenae Rhizoma, which has a long history to be used …

Toxin-induced experimental models of learning and memory impairment

SV More, H Kumar, DY Cho, YS Yun… - International journal of …, 2016 - mdpi.com
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

T Ahmed, SA Enam, AH Gilani - Neuroscience, 2010 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease. There are a limited number of
therapeutic options available for the treatment of AD. Curcuminoids (a mixture of …

Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway

X Li, H Jiang, L Xu, YQ Liu, J Tang, JS Shi, X Yu… - Biochemical …, 2021 - Elsevier
Podocyte injury following abnormal podocyte autophagy plays an indispensable role in
diabetic nephropathy (DN), therefore, restoration of podocyte autophagy is considered as a …

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice

B Lee, K Jung, DH Kim - Pharmacology Biochemistry and Behavior, 2009 - Elsevier
Anemarrhenaasphodeloides Bunge (AA, family Liliaceae), which primarily contains
xantones, such as mangiferin, and steroidal saponins, such as timosaponin AIII and …

Timosaponin AIII induces G2/M arrest and apoptosis in breast cancer by activating the ATM/Chk2 and p38 MAPK signaling pathways

M Zhang, J Qu, Z Gao, Q Qi, H Yin, L Zhu… - Frontiers in …, 2021 - frontiersin.org
Timosaponin AIII (TAIII), a steroidal saponin, exerts potent anti-tumor activity in various
cancers, especially breast cancer. However, the concrete molecular mechanisms of TAIII …

Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease

CM Wang, MY Liu, F Wang, MJ Wei, S Wang… - Pharmacology …, 2013 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
amyloid β (Aβ) deposits, elevated oxidative stress, and apoptosis of the neurons …

The treatment of Alzheimer's disease using Chinese medicinal plants: from disease models to potential clinical applications

Y Su, Q Wang, C Wang, K Chan, Y Sun… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance Alzheimer's disease (AD) is characterized by the
sustained higher nervous disorders of the activities and functions of the brain. Due to its …