Glypican-3 (GPC3) is an oncofetal glycoprotein attached to the cell membrane by a
glycophosphatidylinositol anchor. GPC3 is overexpressed in some kinds of tumors …

Glypican-3 (GPC3) is a cell-surface glycoprotein consisting of heparan sulfate
glycosaminoglycan chains and an inner protein core. It has important functions in cellular …

Although there has been great progress in cancer treatment, cancer remains a serious
health threat to humans because of the lack of biomarkers for diagnosis, especially for early …

Results of immunotherapy in childhood solid cancer have been so far, with the exception of
neuroblastoma, quite disappointing. Lack of knowledge of the immune contexture of these …

Neural migration is a critical step during brain development that requires the interactions of
cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate …

Simple Summary Bone sarcomas are mesenchymal origin tumors. Bone sarcoma patients
show a variable response or do not respond to chemotherapy. Notably, improving efficient …

Every year, approximately 600 infants, children, and adolescents are diagnosed with renal
cancer in the United States. In addition to Wilms tumor (WT), which accounts for about 80 …

Hepatoblastoma is a malignant tumor in the liver of children that generally occurs at the age
of 2–3 years. There have been ample evidence from the preclinical as well as clinical …

Hepatocellular carcinoma (HCC) is a malignant tumor of hepatocytes. It is a common
malignant tumor of the digestive system that often has initially hidden presentation followed …

ABSTRACT A bispecific antibody (bsAb) can simultaneously bind two different epitopes or
antigens, allowing for multiple mechanistic functions with synergistic effects. BsAbs have …