Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs
is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug …

The nasal mucociliary clearance system transports the mucus layer that covers the nasal
epithelium towards the nasopharynx by ciliary beating. Its function is to protect the …

Respiratory gene therapy has been considered for the treatment of a broad range of
pulmonary disorders. However, respiratory secretions form an important barrier towards the …

Drug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics–
pharmacodynamics associated with systemic therapies. For many drug therapies, there is …

Mucociliary clearance (MC), designed by evolution to eliminate inhaled and possibly
noxious material from the airways, considerably limits the benefit of inhalation therapy …

A widely investigated approach to bypass the blood brain barrier is represented by the
intranasal delivery of therapeutic agents exploiting the olfactory or trigeminal connections …

The conversion of colloidal drug carriers/polymeric nanoparticles into dry microparticulate
powders (eg, by spray-drying) is a prominent approach to overcome the aerodynamic …

Introduction: Antiemetic drugs are used in the treatment of nausea and emesis.
Development of novel delivery systems for antiemetic drugs, as an alternative to …

Objectives The current review gives an overview of the anatomical and cellular structure of
the nasal cavity. It presents some possibilities and different techniques to enhance the drug …

Lung surfactant has been observed at all surfaces of the airway lining fluids and is an
important contributor to normal lung function. In the conducting airways, the surfactant film …