Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
[HTML][HTML] Memantine for the treatment of dementia: a review on its current and future applications
J Folch, O Busquets, M Ettcheto… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …
Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …
Microtubule-associated protein tau in development, degeneration and protection of neurons
JZ Wang, F Liu - Progress in neurobiology, 2008 - Elsevier
As a principal neuronal microtubule-associated protein, tau has been recognized to play
major roles in promoting microtubule assembly and stabilizing the microtubules and to …
major roles in promoting microtubule assembly and stabilizing the microtubules and to …
Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice
This study found that (a) administration of a relatively low dose of ketamine to mice inhibits
brain glycogen synthase kinase-3 (GSK3),(b) this inhibition of GSK3 is necessary for rapid …
brain glycogen synthase kinase-3 (GSK3),(b) this inhibition of GSK3 is necessary for rapid …
Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions
RS Jope, MS Roh - Current drug targets, 2006 - ingentaconnect.com
Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …
Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging
Introduction: Glycogen synthase kinase 3 (GSK3) is at the center of cellular signaling and
controls various aspects of brain functions, including development of the nervous system …
controls various aspects of brain functions, including development of the nervous system …
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
LQ Zhu, SH Wang, D Liu, YY Yin, Q Tian… - Journal of …, 2007 - Soc Neuroscience
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …
Impaired Wnt signaling in the prefrontal cortex of Alzheimer's disease
Wnt pathway is involved in synaptic plasticity and neuronal survival, and alterations in Wnt
signaling have previously been reported both in aging and neurodegenerative diseases …
signaling have previously been reported both in aging and neurodegenerative diseases …