Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …

Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …

As a principal neuronal microtubule-associated protein, tau has been recognized to play
major roles in promoting microtubule assembly and stabilizing the microtubules and to …

This study found that (a) administration of a relatively low dose of ketamine to mice inhibits
brain glycogen synthase kinase-3 (GSK3),(b) this inhibition of GSK3 is necessary for rapid …

Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …

Introduction: Glycogen synthase kinase 3 (GSK3) is at the center of cellular signaling and
controls various aspects of brain functions, including development of the nervous system …

Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …

Wnt pathway is involved in synaptic plasticity and neuronal survival, and alterations in Wnt
signaling have previously been reported both in aging and neurodegenerative diseases …