The incidence of thyroid cancer (TC) has increased worldwide over the past four decades.
TC is divided into three main histological types: differentiated (papillary and follicular TC) …

The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

Simple Summary Anaplastic thyroid carcinoma (ATC) has a dismal prognostic.
Chemotherapy and radiotherapy are the mainstem options for patients with ATC. In selected …

The treatment options for advanced papillary thyroid cancer (PTC) and anaplastic thyroid
cancer (ATC) refractory to standard therapies are limited. Although anti-PD-1 therapy has a …

The molecular characterization of poorly and anaplastic thyroid carcinomas has been
greatly improved in the last years following the advent of high throughput technologies …

One of the most important steps forward in the management of cancer was the discovery of
immunotherapy. It has become an essential pillar in the treatment paradigm of cancer …

Anaplastic thyroid cancer (ATC) is one of the most lethal of all cancers. It is more common in
women and occurs primarily in older patients. ATC has a median overall survival of 3–5 …

Background The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2
are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express …

In the past decade, the field of cancer immunotherapy has been revolutionized by immune
checkpoint blockade (ICB) technologies. Success across a broad spectrum of cancers has …

Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …