Complexes of ruthenium (II) as promising dual-active agents against cancer and viral infections

A D'Amato, A Mariconda, D Iacopetta, J Ceramella… - Pharmaceuticals, 2023 - mdpi.com
Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …

Revolutionizing anticancer treatment: Ruthenium-based nanoplatforms pave new paths

D Karati, S Meur, S Mukherjee, S Roy - Coordination Chemistry Reviews, 2024 - Elsevier
Cancer ranks among the top causes of mortality on a global scale. The only treatments
available for cancer nowadays are surgery, radiation therapy, and the use of cytotoxic …

Neoadjuvant hyperthermia combined with hybrid nanoarchitectures enhances chemoradiotherapy efficacy in head and neck carcinoma

P Sarogni, V Frusca, A Zamborlin… - … Applied Materials & …, 2024 - ACS Publications
Head and neck squamous cell carcinomas are characterized by a high incidence of
recurrence, especially in patients with locally advanced disease. Standard treatment …

Drug-Free Hybrid Nanoarchitecture Modulation of the Metastatic Behavior of Pancreatic Ductal Adenocarcinoma in Alternative in Vivo Models

A Zamborlin, P Sarogni, V Frusca… - ACS Applied Nano …, 2023 - ACS Publications
Metastasis is the key cause of treatment failure in most oncological patients. The spreading
of cancer cells to distal tissues and organs can be associated with the epithelial-to …

[HTML][HTML] Organic Selenium induces ferroptosis in pancreatic cancer cells

R Noe, N Inglese, P Romani, T Serafini, C Paoli… - Redox Biology, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal
functions to support growth. At the same time, this causes significant dishomeostasis of free …

Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation

R Cazzoli, A Zamborlin, ML Ermini, A Salerno… - RSC …, 2023 - pubs.rsc.org
The key properties and high versatility of metal nanoparticles have shed new perspectives
on cancer therapy, with copper nanoparticles gaining great interest because of the ability to …

Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications

MT Aminzai, M Yildirim, E Yabalak - Talanta, 2024 - Elsevier
Metallic nanoparticles (MNPs) have attracted great interest among scientists and
researchers for years due to their unique optical, physiochemical, biological, and magnetic …

Tumor growth-arrest effect of tetrahydroquinazoline-derivative human topoisomerase II-alpha inhibitor in HPV-negative head and neck squamous cell carcinoma

P Sarogni, N Brindani, A Zamborlin, A Gonnelli… - Scientific Reports, 2024 - nature.com
Oral malignancies continue to have severe morbidity with less than 50% long-term survival
despite the advancement in the available therapies. There is a persisting demand for new …

Copper nano-architecture topical cream for the accelerated recovery of burnt skin

ML Ermini, M Summa, A Zamborlin, V Frusca… - Nanoscale …, 2023 - pubs.rsc.org
Skin burns are debilitating injuries with significant morbidity and mortality associated with
infections and sepsis, particularly in immunocompromised patients. In this context …

[HTML][HTML] Invasiveness modulation of glioma cells by copper complex-loaded nanoarchitectures

A Zamborlin, F Pagliari, ML Ermini, V Frusca… - Colloids and Surfaces B …, 2025 - Elsevier
Among the tumors with the highest lethality, gliomas are primary brain tumors associated
with common recurrence inclined to metastasize along the neuraxis and occasionally out of …