[HTML][HTML] Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
A Miyajima, M Tanaka, T Itoh - Cell stem cell, 2014 - cell.com
The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …
Orchestrating liver development
M Gordillo, T Evans, V Gouon-Evans - Development, 2015 - journals.biologists.com
The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …
burden. Understanding how this complex organ develops during embryogenesis will yield …
[HTML][HTML] The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future
Y Watanabe, A Tsuchiya, S Terai - Clinical and molecular …, 2021 - ncbi.nlm.nih.gov
Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …
[PDF][PDF] Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells
K Si‐Tayeb, FK Noto, M Nagaoka, J Li, MA Battle… - …, 2010 - Wiley Online Library
There exists a worldwide shortage of donor livers available for orthotropic liver
transplantation and hepatocyte transplantation therapies. In addition to their therapeutic …
transplantation and hepatocyte transplantation therapies. In addition to their therapeutic …
[HTML][HTML] Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
Human pluripotent stem cell (hPSC) differentiation typically yields heterogeneous
populations. Knowledge of signals controlling embryonic lineage bifurcations could …
populations. Knowledge of signals controlling embryonic lineage bifurcations could …
Development of the liver: Insights into organ and tissue morphogenesis
EA Ober, FP Lemaigre - Journal of hepatology, 2018 - Elsevier
Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
Members of the IL-6 cytokine family are involved in a variety of biological responses,
including the immune response, inflammation, hematopoiesis, and oncogenesis by …
including the immune response, inflammation, hematopoiesis, and oncogenesis by …
[HTML][HTML] Organogenesis and development of the liver
K Si-Tayeb, FP Lemaigre, SA Duncan - Developmental cell, 2010 - cell.com
Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …
diverse areas of developmental and cell biology. Understanding the fundamental …
[PDF][PDF] Directed differentiation of human embryonic stem cells into functional hepatic cells
The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for
therapeutic applications. We report a novel three‐stage method to efficiently direct the …
therapeutic applications. We report a novel three‐stage method to efficiently direct the …
The Stat family in cytokine signaling
JN Ihle - Current opinion in cell biology, 2001 - Elsevier
During the past few years studies from several laboratories have utilized gene disruption
approaches to define the function of members of the Stat family of transcription factors. The …
approaches to define the function of members of the Stat family of transcription factors. The …