Leveraging artificial intelligence in the fight against infectious diseases
Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …
infectious disease remains an ominous threat to public health. Addressing the challenges …
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections
Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …
effector immune defense molecules in multicellular organisms. AMPs exert their …
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences
J Huang, Y Xu, Y Xue, Y Huang, X Li, X Chen… - Nature Biomedical …, 2023 - nature.com
Systematically identifying functional peptides is difficult owing to the vast combinatorial
space of peptide sequences. Here we report a machine-learning pipeline that mines the …
space of peptide sequences. Here we report a machine-learning pipeline that mines the …
Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health
T Li, Z Wang, J Guo, C de la Fuente-Nunez… - Science of The Total …, 2023 - Elsevier
The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …
Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning
Molecular de-extinction could offer avenues for drug discovery by reintroducing bioactive
molecules that are no longer encoded by extant organisms. To prospect for antimicrobial …
molecules that are no longer encoded by extant organisms. To prospect for antimicrobial …
Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal
A Tarín-Pelló, B Suay-García… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction Antibiotic resistance is one of the biggest public health threats worldwide.
Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent …
Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent …
[HTML][HTML] Deep generative models for peptide design
F Wan, D Kontogiorgos-Heintz… - Digital …, 2022 - pubs.rsc.org
Computers can already be programmed for superhuman pattern recognition of images and
text. For machines to discover novel molecules, they must first be trained to sort through the …
text. For machines to discover novel molecules, they must first be trained to sort through the …
Conditional antimicrobial peptide therapeutics
Antimicrobial peptides (AMPs) constitute a promising class of alternatives to antibiotics to
curb antimicrobial resistance. Nonetheless, their utility as a systemic agent is hampered by …
curb antimicrobial resistance. Nonetheless, their utility as a systemic agent is hampered by …
Antibiotic discovery in the artificial intelligence era
T Lluka, JM Stokes - Annals of the New York Academy of …, 2023 - Wiley Online Library
As the global burden of antibiotic resistance continues to grow, creative approaches to
antibiotic discovery are needed to accelerate the development of novel medicines. A rapidly …
antibiotic discovery are needed to accelerate the development of novel medicines. A rapidly …
Synthetic molecular evolution of antimicrobial peptides
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …