This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

Hydrophilic polymer gels (hydrogels) exhibit a range of physical, chemical, and biological
properties which makes them attractive as drug delivery systems. Such systems are …

The Handbook of Pharmaceutical Controlled Release Technology reviews the design,
fabrication, methodology, administration, and classifications of various drug delivery …

A physiological flow model is presented to account for plasma level double peaks based on
cyclical gastric emptying and intestinal motility in the fasted state. Central to the model is the …

The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated
artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in …

Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor
aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) …

This chapter reviews oral controlled-release (CR) systems, with a focus on dosage-form
characteristics and gastrointestinal (GI) physiology. Since an understanding of the basic …

In a previous study, we developed a multiple-unit type of oral floating dosage system, which
is a new type of floating pill composed of both an effervescent layer and a swellable …

Among the most critical parameters for any drug candidate are tolerability, dose, solubility
and permeability. For controlled release formulations, gastrointestinal transit is an added …

Human biorelevant media have been shown to be a useful tool in pharmaceutical
development and to provide input for in silico prediction of pharmacokinetic profiles after oral …