Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control
The Nε-methyl lysine status of histones is important in the regulation of eukaryotic
transcription. The Fe (II) and 2-oxoglutarate (2OG)-dependent JmjC domain enzymes are …
transcription. The Fe (II) and 2-oxoglutarate (2OG)-dependent JmjC domain enzymes are …
Control of protein function by reversible Nɛ-lysine acetylation in bacteria
S Thao, JC Escalante-Semerena - Current opinion in microbiology, 2011 - Elsevier
Recently published work indicates that reversible Nɛ-lysine (Nɛ-Lys) acetylation of proteins
in bacteria may be as diverse, and as important for cellular function, as it has been reported …
in bacteria may be as diverse, and as important for cellular function, as it has been reported …
Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria
JM Moore, E Bradshaw, RF Seipke, MI Hutchings… - Methods in …, 2012 - Elsevier
Secondary metabolite production from Streptomyces bacteria is primarily controlled at the
level of transcription. Under normal laboratory conditions, the majority of the biosynthetic …
level of transcription. Under normal laboratory conditions, the majority of the biosynthetic …
Targeting cancer using KAT inhibitors to mimic lethal knockouts
Two opposing enzyme classes regulate fundamental elements of genome maintenance,
gene regulation and metabolism, either through addition of an acetyl moiety by histone …
gene regulation and metabolism, either through addition of an acetyl moiety by histone …
Chemical and biochemical approaches in the study of histone methylation and demethylation
KK Li, C Luo, D Wang, H Jiang… - Medicinal research …, 2012 - Wiley Online Library
Histone methylation represents one of the most critical epigenetic events in DNA function
regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide …
regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide …
HISTome2: a database of histone proteins, modifiers for multiple organisms and epidrugs
Background Epigenetics research is progressing in basic, pre-clinical and clinical studies
using various model systems. Hence, updating the knowledge and integration of biological …
using various model systems. Hence, updating the knowledge and integration of biological …
Epigenetics and the endocannabinoid system signaling: An intricate interplay modulating neurodevelopment
The endocannabinoid (eCB) system is a complex system comprising endogenous
cannabinoids (eCBs), their synthesis and degradation enzymes, and cannabinoid receptors …
cannabinoids (eCBs), their synthesis and degradation enzymes, and cannabinoid receptors …
JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression
X Shen, Z Zhuang, Y Zhang, Z Chen, L Shen, W Pu… - Tumor Biology, 2015 - Springer
Although three therapeutic modalities (surgical resection, chemotherapy, and radiotherapy)
have been established, long-term survival for lung cancer patients is still generally poor …
have been established, long-term survival for lung cancer patients is still generally poor …
Role of epigenetics in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers,
associated with poor survival outcomes. Lack of early diagnosis, resistance to conventional …
associated with poor survival outcomes. Lack of early diagnosis, resistance to conventional …
Epigenome engineering in cancer: fairytale or a realistic path to the clinic?
F Falahi, A Sgro, P Blancafort - Frontiers in oncology, 2015 - frontiersin.org
Epigenetic modifications such as histone post-transcriptional modifications, DNA
methylation, and non-protein-coding RNAs organize the DNA in the nucleus of eukaryotic …
methylation, and non-protein-coding RNAs organize the DNA in the nucleus of eukaryotic …