MEC-17, a newly identified alpha-tubulin-N-acetyltransferase 1, serves as the major α-
tubulin acetyltransferase to promote α-tubulin acetylation in vitro and in vivo. Alteration of α …

Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines
in the activation phase of inflammation, particularly through mitogen-activated protein …

Dysfunctions in NAD+ metabolism are associated with neurodegenerative diseases, acute
brain injury, diabetes, and aging. Loss of NAD+ levels results in impairment of mitochondria …

Gcn5 is a conserved acetyltransferase that regulates transcription by acetylating the N-
terminal tails of histones. Motivated by recent studies identifying a chemically diverse array …

Epidemiological studies have shown significant results in the interaction between the
functions of brain-derived neurotrophic factor (BDNF) and 5-HT in mood disorders, such as …

Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present
or recognized prior to pregnancy. Several risk factors of GDM depend on environmental …

The purpose of this review is to introduce the exciting field of epigenetics and to describe
how it could explain the mechanisms by which environmental changes induce pathological …

DNA methylation, histone modifications, and non-coding RNAs are ubiquitous in the animal
kingdom. Histone modifications are apparently similar in all higher animal taxa but DNA …

Chaperones influence histone conformation and intermolecular interaction in multiprotein
complexes, and the structures obtained with full-length histones often provide more accurate …

Mitochondria are a unique intracellular organelle due to their evolutionary origin and
multifunctional role in overall cellular physiology and pathophysiology. To meet the specific …