Highlights•“Old” molecules and targets represent attractive start points.•Modern medicinal
chemistry is essential to convert a compound hit into a drug.•Nutritional flexibility makes …

Introduction Tuberculosis remains a significant concern in global public health due to its
intricate biology and propensity for developing antibiotic resistance. Discovering new drugs …

Natural products provide a rich source of potential antimicrobials for treating infectious
diseases for which drug resistance has emerged. Foremost among these diseases is …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest
infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu …

The therapeutic potential of 3H-pyrrolo [2, 3-c] quinolines—the main core of Marinoquinoline
natural products—has been explored for the development of new anti-TB agents. The …

The ability of bacterial pathogens to regulate growth is crucial to control homeostasis,
virulence, and drug response. Yet, we do not understand the growth and cell cycle …

Tuberculosis (TB), one of the most prevalent infections, is on the rise today. Although there
are drugs available in the market to combat this lethal disorder, there are several …

Using purine as a scaffold, the methods for preparation of novel 2-aminopurine and purine
derivatives substituted at position C 6 by the fragments of natural amino acids, short …

The housecleaning enzyme of Mycobacterium tuberculosis (Mtb), MazG, is a nucleoside
triphosphate pyrophosphohydrolase (NTP-PPase) and can hydrolyze all canonical or non …

Discovering new antibacterial agents is crucial to addressing the increasing risk of bacterial
infections induced by antimicrobial resistance in food and agricultural industries. Here …