ANCA vasculitis has an associated autoimmune response that produces ANCAs that induce
distinct pathologic lesions. Pauci-immune necrotizing and crescentic GN is a frequent …

Antineutrophil cytoplasmic autoantibodies (ANCAs) are the probable cause of a distinct form
of vasculitis that can be accompanied by necrotizing granulomatosis. Clinical and …

This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …

For over a century, acute 'post-streptococcal glomerulonephritis'(APSGN) was the
prototypical form of bacterial infection-associated glomerulonephritis, typically occurring …

Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …

IgA nephropathy is defined by the presence of IgA-dominant or co-dominant immune
deposits within glomeruli. Biopsy specimens meeting these diagnostic criteria have a range …

Hypertensive nephrosclerosis is the second most common cause of end-stage renal disease
after diabetes. For years, hypertensive kidney disease has been focused on the afferent …

BK virus maintains a latent infection that is ubiquitous in humans. It has a propensity for
reactivation in the setting of a dysfunctional cellular immune response and is frequently …

Diabetes mellitus (DM) afflicting humans has been recognized as a disease for> 3000 years.
However, very little was known about its etiology and pathogenesis until about a century ago …

The pathogenesis of the development of sclerotic lesions in focal segmental
glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or …