Polo-like kinase 1 (PLK1) is an essential protein kinase with multiple roles in mitotic
progression. PLK1 consists of a kinase domain (KD) and a phosphopeptide-binding polobox …

Green tea, a popular and healthy nonalcoholic drink consumed globally, is abundant in
natural polyphenols. One of these polyphenols is epigallocatechin-3-gallate (EGCG), which …

Polo-like kinase 1 (Plk1) is considered an attractive target for anticancer therapy. Over the
years, studies on the noncatalytic polo-box domain (PBD) of Plk1 have raised the …

PLK1 is found to be highly expressed in various types of cancers, but the development of
inhibitors for it has been slow. Most inhibitors are still in clinical stages, and many lack the …

Abstract Background Polo-like kinases (PLKs) are a kinase class of serine/threonine with
five members that play crucial roles in cell cycle regulation. However, their biological …

Inflammatory signals from immunological cells may cause damage to intestinal epithelial
cells (IECs), resulting in intestinal inflammation and tissue impairment. Interferon‐γ …

PLK-1 (Polo-like kinase-1) plays an essential role in cytokinesis, and its aberrant expression
is considered to be keenly associated with a wide range of cancers. It has been selected as …

Background Polo-like kinase 1 (PLK1) is a critical therapeutic target in the treatment of head
and neck squamous cell carcinoma (HNSCC). The objective of this study was to investigate …

Novel therapeutic approaches are needed for the treatment of Ewing sarcoma tumors. We
previously identified that Ewing sarcoma cell lines are sensitive to drugs that inhibit protein …

Abstract Polo-like kinase 1 (PLK1) is a serine/threonine kinase cell cycle modulator and a
highly significant biomarker in chemotherapy. Cancer treatment strategies now prioritize …