Regulation of mitophagy and mitochondrial function: Natural compounds as potential therapeutic strategies for Parkinson's disease
H Liang, Z Ma, W Zhong, J Liu… - Phytotherapy …, 2024 - Wiley Online Library
Mitochondrial damage is associated with the development of Parkinson's disease (PD),
indicating that mitochondrial‐targeted treatments could hold promise as disease‐modifying …
indicating that mitochondrial‐targeted treatments could hold promise as disease‐modifying …
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis
J Zhao, T Yang, J Yi, H Hu, Q Lai, L Nie, M Liu, C Chu… - Iscience, 2024 - cell.com
Doxorubicin induces myocardial injury and fibrosis. Still, no effective interventions are
available. AP39 is an H 2 S donor that explicitly targets mitochondria. This study investigated …
available. AP39 is an H 2 S donor that explicitly targets mitochondria. This study investigated …
Mitochondrial calcium uniporter complex: Unveiling the interplay between its regulators and calcium homeostasis
J Guo, Y Wang, C Shi, D Zhang, Q Zhang, L Wang… - Cellular …, 2024 - Elsevier
The mitochondrial calcium uniporter complex (MCUc), serving as the specific channel for
calcium influx into the mitochondrial matrix, is integral to calcium homeostasis and cellular …
calcium influx into the mitochondrial matrix, is integral to calcium homeostasis and cellular …
[HTML][HTML] Canagliflozin inhibits PASMCs proliferation via regulating SGLT1/AMPK signaling and attenuates artery remodeling in MCT-induced pulmonary arterial …
X Chen, X Yu, G Lian, H Tang, Y Yan, G Gao… - Biomedicine & …, 2024 - Elsevier
Pulmonary arterial hypertension (PAH) was a devastating disease characterized by artery
remodeling, ultimately resulting in right heart failure. The aim of this study was to investigate …
remodeling, ultimately resulting in right heart failure. The aim of this study was to investigate …
Gene Expression Profiling of Post Mortem Midbrain of Parkinson's Disease Patients and Healthy Controls
M Salemi, M Ravo, G Lanza, FA Schillaci… - International Journal of …, 2024 - mdpi.com
Parkinson's disease (PD) stands as the most prevalent degenerative movement disorder,
marked by the degeneration of dopaminergic neurons in the substantia nigra of the …
marked by the degeneration of dopaminergic neurons in the substantia nigra of the …
[HTML][HTML] Mitophagy in the Pathogenesis of Obesity-Associated Cardiovascular Diseases: New Mechanistic and Therapeutic Insights
K Huang, J Ren - tmr.scione.com
Mitophagy, a crucial mechanism for maintaining mitochondrial quality, involves the selective
removal of damaged and potentially harmful mitochondria through autophagy. Despite its …
removal of damaged and potentially harmful mitochondria through autophagy. Despite its …